Cameron Laboratories



Houston, S., Gomez, A., Geppert, A., Eshghi, A., Smith, D.S., Waugh, S., Hardie, D.B., Goodlett, D.R., and Cameron, C.E. Deep proteome coverage advances knowledge of Treponema pallidum protein expression profiles during infection. Scientific Reports 13, 18259 (2023).

Waugh, S., Ranasinghe, A., Gomez, A., Houston, S., Lithgow, K.V., Eshghi, A., Fleetwood, J., Conway, K., Reynolds, L.A., and Cameron, C.E. Syphilis and the host; multi-omic analysis of host cellular responses to Treponema pallidum provides novel insight into syphilis pathogenesis. Frontiers in Microbiology. 14:1254342. doi: 10.3389/fmicb.2023.1254342

Pětrošová H, Mikhael A, Culos S, Giraud-Gatineau A, Gomez A.M., Sherman M.E., Ernst R.K., Cameron C.E., Picardeau M, Goodlett DR. Lipid A structural diversity among members of the genus Leptospira. Front. Microbiol. 14:1181034. doi: 10.3389/fmicb.2023.1181034

Lukehart, S.A., Molini, B., Gomez, A., Godorness, C., Hof, R., Fernandez, M.C., Pitner, R.A., Gray, S.A., Carter, D., Giacani, L., Cameron, C.E. 2022. Immunization with a tri-antigen syphilis vaccine significantly attenuates chancre development, reduces bacterial load, and inhibits dissemination of Treponema pallidum. Vaccine. Volume 40, Issue 52, Pages 7676-7692, ISSN 0264-410X,

Jennings JM, Grieb SM, Rietmeijer C, Gaydos CA, Hawkins R, Thurston RC, Blanchard J, Cameron CE, Lewis DA. Advancing Sexual Harassment Prevention and Elimination in the Sciences: “Every …health organization must do something similar.” Sexually Transmitted Diseases. October 2022 – Volume 49 – Issue 10 – p 663-668 doi: 10.1097/OLQ.0000000000001683

Houston, S., Schovanek, E., Conway, K.M.E., Mustafa, S., Gomez, A., Ramaswamy, R., Haimour, A., Boulanger, M.J., Reynolds, L. A., and Cameron, C.E. 2022. Identification and Functional Characterization of Peptides with Antimicrobial Activity from the Syphilis Spirochete, Treponema pallidum. Front. Microbiol. doi: 10.3389/fmicb.2022.888525.

Li C, Sutherland D, Hammond SA, Yang C, Taho F, Bergman L, Houston S, Warren RL, Wong T, Hoang LMN, Cameron CE, Helbing CC, Birol I. 2022. AMPlify: attentive deep learning model for discovery of novel antimicrobial peptides effective against WHO priority pathogens. BMC Genomics. 23(1):77. doi: 10.1186/s12864-022-08310-4.

Lithgow, K.V., Tsao, E., Schovanek, E., Gomez, A., Swayne, L.A., and Cameron, C.E. 2021. Treponema pallidum disrupts VE-cadherin intracellular junctions and traverses endothelial barriers using a cholesterol-dependent mechanism. Frontiers in Microbiology. 12:691731. doi: 10.3389/fmicb.2021.691731

Plotnikoff, K., Donken, R., Smith, L., Cameron, C., LaMontagne, D. S., Bettinger, J., Sadarangani, M., Grennan, T., Racey, C.S., Hybiske, K., Naus, M., Monteiro, A., and Ogilvie, G. 2021. Priorities for sexually transmitted infection vaccine research and development: Results from a survey of global leaders and representatives. Vaccine: X. Doi:

STI Vaccine Symposium Report:

Lithgow, K.V., Church, B., Gomez, A., Tsao, E., Houston, S., Swayne, L.A., and Cameron, C.E. 2020. Identification of the Neuroinvasive Pathogen Host Target, LamR, as an Endothelial Receptor for the Treponema pallidum Adhesin Tp0751. mSphere 5:e00195-20.

Ramaswamy, R., Houston, S., Loveless, B., Cameron, C.E., and Boulanger, M.J. 2019. Structural characterization of Treponema pallidum Tp0225 reveals an unexpected leucine-rich repeat architecture. Acta Crystallogr F Struct Biol Commun. 75(Pt 7):489-495. DOI: 10.1107/S2053230X19007726.

Helbing, C., Hammond, S.A., Jackman, S., Houston, S., Warren, R., Cameron, C. and Birol, I. 2019. Antimicrobial peptides from Rana [Lithobates] catesbeiana: Gene structure and bioinformatic identification of novel forms from tadpoles. Scientific Reports. 9:1529.

Church, B., Wall, E., Webb, J.R., and Cameron, C.E. 2019. Interaction of Treponema pallidum, the syphilis spirochete, with human platelets. PLOS One. 14(1): e0210902.

Osbak, K.K., Van Raemdonck, G.A., Dom, M., Cameron, C.E., Meehan, C.J., Deforce, D., Van Ostade, X., Kenyon, C.R., Dhaenenn, D. 2018. Candidate Treponema pallidum biomarkers uncovered in urine from individuals with syphilis using mass spectrometry. Future Microbiology. DOI: 10.2217/fmb-2018-0182.

Cameron, C.E. 2018. Syphilis Vaccine Development: Requirements, Challenges and Opportunities.  Sexually Transmitted Diseases. DOI: 10.1097/OLQ.0000000000000831

Houston, S., Lithgow, K.V., Osbak, K.K., Kenyon, C.R. and Cameron, C.E. 2018. Functional insights from proteome-wide structural modeling of Treponema pallidum subspecies pallidum, the causative agent of syphilis. BMC Struct Biol. 18(1):7. Doi: 10.1186/s12900-018-0086-3.

Rekart, M.L., Ndifon, W., Brunham, R.C., Dushoff, J., Park, S.W., Rawat, S., and Cameron, C.E. 2017. A Double-Edged Sword: does highly active antiretroviral therapy (HAART) contribute to syphilis incidence by impairing immunity to Treponema pallidum? Sexually Transmitted Infections. doi:10.1136/sextrans-2016-052870.

Kao, W.C.A., Petrosova, H., Ebady, R., Lithgow, K.V., Rojas, P., Zhang, Y., Kim, Y.R., Gupta, N., Moter, A., Cameron, C.E., Moriarty, T.J. 2017. Identification of Tp0751 (Pallilysin) as a Treponema pallidum vascular adhesin by heterologous expression in the Lyme disease spirochete. Scientific Reports. 7:1538.

Raverty, S.A., Rhodes, L.D., Zabek, E., Eshghi, A., Cameron, C.E., Hanson, M.B., and Schroeder, J.P. Respiratory Microbiome of Endangered Southern Resident Killer Whales and Microbiota of Surrounding Sea Surface Microlayer in the Eastern North Pacific. Sci Rep 7, 394 (2017).

Petrosova, H., Eshghi, A., Anjum, Z., Zlotnikov, N., Cameron, C.E., Moriarty, T.J. 2017. Diet-induced obesity does not alter tigecycline treatment efficacy in murine Lyme disease. Frontiers in Microbiology. 8:292.

Lithgow, K.V., Hof, R., Wetherell, C., Phillips, D., Houston, S. and Cameron, C.E. 2017. A defined syphilis vaccine candidate inhibits Treponema pallidum dissemination. Nature Communications. 8:14273. Doi: 10.1038/ncomms14273.

Cameron, C.E. 2017. A journey through time: the foundational studies of Dr. James N. Miller and their influence on current day syphilis research. Forum on Immunopathological Diseases and Therapeutics. DOI: 10.1615/ForumImmunDisTher.2017020116

Champredon, D., Cameron, C.E., Smieja, M., Dushoff, J. 2016. Epidemiological impact of a vaccine against syphilis: a simulation study. Epidemiology and Infection. 144, 3244-3252.

Parker, M.L.*, Houston, S.*, Wetherell, C., Cameron, C.E.#, Boulanger, M.J.# 2016. The structure of Treponema pallidum Tp0624 reveals a modular assembly of previously uncharacterized and neofunctionalized domains. PLoS One. 11:e0166274

Parker, M.L.*, Houston, S.*, Lithgow, K.V., Kao, W., Moriarty, T.J., Cameron, C.E.#, Boulanger, M.J.# 2016. The structure of Treponema pallidum Tp0751 (pallilysin) reveals a lipocalin-like fold that mediates adhesion to extracellular matrix components and interactions with host cells. PLoS Pathogens. 12:e1005919.

Osbak, K.K., Houston, S., Lithgow, K.V., Meehan, C., Strouhal, M., Šmajs, D., Cameron, C.E., Van Ostade, X., Kenyon, C.R., and Van Raemdonck, G.A. 2016. Characterizing the Syphilis-Causing Treponema pallidum ssp. pallidum Proteome Using Complementary Mass Spectrometry. PLOS Neglected Tropical Diseases. 10(9): e0004988.

Lithgow, K.V, Cameron, C.E. 2016. Syphilis vaccine development. Expert Review of Vaccines. PMID: 27328030.

Gottlieb, S.L., Deal, C.D., Giersing, B., Rees, H., Bolan, G., Johnston, C., Timms, P., Gray-Owen, S.D., Jerse, A.E., Cameron, C.E., Moorthy, V.S., Kiarie, J., and Broutet, N. 2016. The global roadmap for advancing development of vaccines against sexually transmitted infections: Update and next steps. Vaccine. 34:2939-2947.

Houston S, Taylor JS, Denchev Y, Hof R, Zuerner RL, Cameron CE. 2015. The host-interacting proteins Tp0750 and pallilysin; conservation among treponemes and restriction of proteolytic capacity to Treponema pallidum. Infect Immun. 83:4204-4216. PMC4598410.

Alt, D., Wilson-Welder, J., Bayles, D., Cameron, C., Adler, B., Bulach, D., Seemann, T., Lehane, M., Haines, L., Darby, A., Hall, N., Radford, A., and Zuerner, R. 2015. Complete genome sequence of Leptospira interrogans serovar Bratislava, Strain PigK151. Genome Announcements.3(3). pii: e00678-15. doi: 10.1128/genomeA.00678-15.

Witchell, T.D., Eshghi, A., Nally, J.E., Hof, R., Boulanger, M.J., Wunder, E.A., Ko, A.I., Haake, D.A. and Cameron, C.E. 2014. Post-translational modification of LipL32 during Leptospira interrogans infection. PLoS Neglected Tropical Diseases. 8(10): e3280. doi:10.1371/journal.pntd.0003280

Houston, S., Taylor, J.S. and Cameron, C.E. 2014. Spirochaetes. Encyclopedia of Life Sciences. John Wiley & Sons, Inc. Chichester [DOI: 10.1002/9780470015902.a0000466.pub3]

Cameron, C.E. and S.A. Lukehart. 2014. Current status of syphilis vaccine development: need, challenges, prospects. Vaccine. 32:1602-1609. PMC3951677.

Houston, S., Russell, S., Hof, R., Roberts, A.K., Cullen, P., Irvine, K., Smith, D.S., Borchers, C.H., Tonkin, M.L., Boulanger, M.J., and Cameron, C.E. 2014. The multifunctional role of the pallilysin-associated Treponema pallidum protein, Tp0750, in promoting fibrinolysis and extracellular matrix component degradation. Molecular Microbiology. 91:618-634. PMC3954913.

Smith, B.C., Y. Simpson, M.G. Morshed, L.L.E. Cowen, R. Hof, C. Wetherell, and C.E. Cameron. 2013. Syphilis diagnosis – new proteins for a new perspective. Journal of Clinical Microbiology. 51:105-111. PMC3536202.

Eshghi, A., K. Lourdault, G. Murray, T. Bartpho, R.W. Sermswan, M. Picardeau, B. Adler, B. Snarr, R. L. Zuerner, and C.E. Cameron. 2012. Leptospira interrogans catalase is required for resistance to H2O2 and for virulence.  Infection and Immunity. 80:3892-3899. PMC3486042.

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