Cameron Laboratory, Department of Biochemistry and Microbiology
1 (250) 853-3190
caroc@uvic.ca

Publications

Publications

2018

Osbak, K.K., Van Raemdonck, G.A., Dom, M., Cameron, C.E., Meehan, C.J., Deforce, D., Van Ostade, X., Kenyon, C.R., Dhaenenn, D. 2018. Candidate Treponema pallidum biomarkers uncovered in urine from individuals with syphilis using mass spectrometry. Future Microbiology. In press.

Houston, S., Lithgow, K.V., Osbak, K.K., Kenyon, C.R. and Cameron, C.E. 2018. Functional insights from proteome-wide structural modeling of Treponema pallidum subspecies pallidum, the causative agent of syphilis. BMC Struct Biol. 18(1):7. Doi: 10.1186/s12900-018-0086-3.

Cameron, C.E. 2018. Syphilis Vaccine Development: Requirements, Challenges and Opportunities.  Sexually Transmitted Diseases. DOI: 10.1038/s41598-017-01589-4.

2017

Lithgow, K.V., Hof, R., Wetherell, C., Phillips, D., Houston, S. and Cameron, C.E. 2017. A defined syphilis vaccine candidate inhibits Treponema pallidum dissemination. Nature Communications. 8:14273. Doi: 10.1038/ncomms14273.

Rekart, M.L., Ndifon, W., Brunham, R.C., Dushoff, J., Park, S.W., Rawat, S., and Cameron, C.E. 2017. A Double-Edged Sword: does highly active antiretroviral therapy (HAART) contribute to syphilis incidence by impairing immunity to Treponema pallidum? Sexually Transmitted Infections. doi:10.1136/sextrans-2016-052870.

Raverty, S., Rhodes, L., Zabec, E., Eshghi, A., Cameron, C., Hanson, M.B., Schroeder, J. P. 2017. Survey of Microbiota in Exhaled Breath Samples Collected from Endangered Southern Resident Killer Whales and in the Sea Surface Microlayer in the Salish Sea and Northeastern Pacific Regions. Scientific Reports. 7:394.

Cameron, C.E. 2017. A journey through time: the foundational studies of Dr. James N. Miller and their influence on current day syphilis research. Forum on Immunopathological Diseases and Therapeutics. 8: DOI: 10.1615/ForumImmunDisTher.2017020116.

Petrosova, H., Eshghi, A., Anjum, Z., Zlotnikov, N., Cameron, C.E., Moriarty, T.J. 2017. Diet-induced obesity does not alter tigecycline treatment efficacy in murine Lyme disease. Frontiers in Microbiology. 8:292.

Kao, W.C.A., Petrosova, H., Ebady, R., Lithgow, K.V., Rojas, P., Zhang, Y., Kim, Y.R., Gupta, N., Moter, A., Cameron, C.E., Moriarty, T.J. 2017. Identification of Tp0751 (Pallilysin) as a Treponema pallidum vascular adhesin by heterologous expression in the Lyme disease spirochete. Scientific Reports. 7:1538.

2016

Gottlieb, S.L., Deal, C.D., Giersing, B., Rees, H., Bolan, G., Johnston, C., Timms, P., Gray-Owen, S.D., Jerse, A.E., Cameron, C.E., Moorthy, V.S., Kiarie, J., and Broutet, N. 2016. The global roadmap for advancing development of vaccines against sexually transmitted infections: Update and next steps. Vaccine. 34:2939-2947.

Osbak, K.K., Houston, S., Lithgow, K.V., Meehan, C., Strouhal, M., Šmajs, D., Cameron, C.E., Van Ostade, X., Kenyon, C.R., and Van Raemdonck, G.A. 2016. Characterizing the Syphilis-Causing Treponema pallidum ssp. pallidum Proteome Using Complementary Mass Spectrometry. PLOS Neglected Tropical Diseases 10(9): e0004988.

Lithgow, K.V, Cameron, C.E. 2016. Syphilis vaccine development. Expert Review of Vaccines. PMID: 27328030.

Champredon, D., Cameron, C.E., Smieja, M., Dushoff, J. 2016. Epidemiological impact of a vaccine against syphilis: a simulation study. Epidemiology and Infection. 144:3244-3252.

Parker, M.L.*, Houston, S.*, Lithgow, K.V., Kao, W., Moriarty, T.J., Cameron, C.E.#, Boulanger, M.J.# 2016. The structure of Treponema pallidum Tp0751 (pallilysin) reveals a lipocalin-like fold that mediates adhesion to extracellular matrix components and interactions with host cells. PLoS Pathogens. 12:e1005919.

Parker, M.L.*, Houston, S.*, Wetherell, C., Cameron, C.E.#, Boulanger, M.J.# 2016. The structure of Treponema pallidum Tp0624 reveals a modular assembly of previously uncharacterized and neofunctionalized domains. PLoS One. 11:e0166274

2015 and Earlier

Houston S, Taylor JS, Denchev Y, Hof R, Zuerner RL, Cameron CE. 2015. The host-interacting proteins Tp0750 and pallilysin; conservation among treponemes and restriction of proteolytic capacity to Treponema pallidum. Infect Immun. 83:4204-4216. PMC4598410.

Alt, D., Wilson-Welder, J., Bayles, D., Cameron, C., Adler, B., Bulach, D., Seemann, T., Lehane, M., Haines, L., Darby, A., Hall, N., Radford, A., and Zuerner, R. 2015. Complete genome sequence of Leptospira interrogans serovar Bratislava, Strain PigK151. Genome Announcements.3(3). pii: e00678-15. doi: 10.1128/genomeA.00678-15.

Witchell, T.D., Eshghi, A., Nally, J.E., Hof, R., Boulanger, M.J., Wunder, E.A., Ko, A.I., Haake, D.A. and Cameron, C.E. 2014. Post-translational modification of LipL32 during Leptospira interrogans infection. PLoS Neglected Tropical Diseases. 8(10):e3280. doi: 10.1371/journal.pntd.0003280.

Houston, S., Taylor, J.S. and Cameron, C.E. 2014. Spirochaetes. Encyclopedia of Life Sciences. John Wiley & Sons, Inc. Chichester http://www.els.net/ [DOI: 10.1002/9780470015902.a0000466.pub3]

Houston, S., Russell, S., Hof, R., Roberts, A.K., Cullen, P., Irvine, K., Smith, D.S., Borchers, C.H., Tonkin, M.L., Boulanger, M.J., and Cameron, C.E. 2014. The multifunctional role of the pallilysin-associated Treponema pallidum protein, Tp0750, in promoting fibrinolysis and extracellular matrix component degradation. Molecular Microbiology. 91:618-634. PMC3954913.

Cameron, C.E. and S.A. Lukehart. 2014. Current status of syphilis vaccine development: need, challenges, prospects. Vaccine. 32:1602-1609. PMC3951677.

Smith, B.C., Y. Simpson, M.G. Morshed, L.L.E. Cowen, R. Hof, C. Wetherell, and C.E. Cameron. 2013. Syphilis diagnosis – new proteins for a new perspective. Journal of Clinical Microbiology. 51:105-111. PMC3536202.

Eshghi, A., K. Lourdault, G. Murray, T. Bartpho, R.W. Sermswan, M. Picardeau, B. Adler, B. Snarr, R. L. Zuerner, and C.E. Cameron. 2012. Leptospira interrogans catalase is required for resistance to H2O2 and for virulence.  Infection and Immunity. 80:3892-3899. PMC3486042.