Cameron Laboratory, Department of Biochemistry and Microbiology
1 (250) 853-3190
caroc@uvic.ca

Publications

Publications

2018

Cameron, C.E. 2018. Syphilis Vaccine Development: Requirements, Challenges and Opportunities.  Sexually Transmitted Diseases. In press.

2017

Lithgow, K.V., Hof, R., Wetherell, C., Phillips, D., Houston, S. and Cameron, C.E. 2017. A defined syphilis vaccine candidate inhibits Treponema pallidum dissemination. Nature Communications. 8:14273. Doi: 10.1038/ncomms14273.

Rekart, M.L., Ndifon, W., Brunham, R.C., Dushoff, J., Park, S.W., Rawat, S., and Cameron, C.E. 2017. A Double-Edged Sword: does highly active antiretroviral therapy (HAART) contribute to syphilis incidence by impairing immunity to Treponema pallidum? Sexually Transmitted Infections. doi:10.1136/sextrans-2016-052870.

Raverty, S., Rhodes, L., Zabec, E., Eshghi, A., Cameron, C., Hanson, M.B., Schroeder, J. P. 2017. Survey of Microbiota in Exhaled Breath Samples Collected from Endangered Southern Resident Killer Whales and in the Sea Surface Microlayer in the Salish Sea and Northeastern Pacific Regions. Scientific Reports. 7:394.

Cameron, C.E. 2017. A journey through time: the foundational studies of Dr. James N. Miller and their influence on current day syphilis research. Forum on Immunopathological Diseases and Therapeutics. 8: DOI: 10.1615/ForumImmunDisTher.2017020116.

Petrosova, H., Eshghi, A., Anjum, Z., Zlotnikov, N., Cameron, C.E., Moriarty, T.J. 2017. Diet-induced obesity does not alter tigecycline treatment efficacy in murine Lyme disease. Frontiers in Microbiology. 8:292.

Kao, W.C.A., Petrosova, H., Ebady, R., Lithgow, K.V., Rojas, P., Zhang, Y., Kim, Y.R., Gupta, N., Moter, A., Cameron, C.E., Moriarty, T.J. 2017. Identification of Tp0751 (Pallilysin) as a Treponema pallidum vascular adhesin by heterologous expression in the Lyme disease spirochete. Scientific Reports. 7:1538.

2016

Gottlieb, S.L., Deal, C.D., Giersing, B., Rees, H., Bolan, G., Johnston, C., Timms, P., Gray-Owen, S.D., Jerse, A.E., Cameron, C.E., Moorthy, V.S., Kiarie, J., and Broutet, N. 2016. The global roadmap for advancing development of vaccines against sexually transmitted infections: Update and next steps. Vaccine. 34:2939-2947.

Osbak, K.K., Houston, S., Lithgow, K.V., Meehan, C., Strouhal, M., Šmajs, D., Cameron, C.E., Van Ostade, X., Kenyon, C.R., and Van Raemdonck, G.A. 2016. Characterizing the Syphilis-Causing Treponema pallidum ssp. pallidum Proteome Using Complementary Mass Spectrometry. PLOS Neglected Tropical Diseases 10(9): e0004988.

Lithgow, K.V, Cameron, C.E. 2016. Syphilis vaccine development. Expert Review of Vaccines. PMID: 27328030.

Champredon, D., Cameron, C.E., Smieja, M., Dushoff, J. 2016. Epidemiological impact of a vaccine against syphilis: a simulation study. Epidemiology and Infection. 144:3244-3252.

Parker, M.L.*, Houston, S.*, Lithgow, K.V., Kao, W., Moriarty, T.J., Cameron, C.E.#, Boulanger, M.J.# 2016. The structure of Treponema pallidum Tp0751 (pallilysin) reveals a lipocalin-like fold that mediates adhesion to extracellular matrix components and interactions with host cells. PLoS Pathogens. 12:e1005919.

Parker, M.L.*, Houston, S.*, Wetherell, C., Cameron, C.E.#, Boulanger, M.J.# 2016. The structure of Treponema pallidum Tp0624 reveals a modular assembly of previously uncharacterized and neofunctionalized domains. PLoS One. 11:e0166274

2015 and Earlier

Houston S, Taylor JS, Denchev Y, Hof R, Zuerner RL, Cameron CE. 2015. The host-interacting proteins Tp0750 and pallilysin; conservation among treponemes and restriction of proteolytic capacity to Treponema pallidum. Infect Immun. 83:4204-4216. PMC4598410.

Alt, D., Wilson-Welder, J., Bayles, D., Cameron, C., Adler, B., Bulach, D., Seemann, T., Lehane, M., Haines, L., Darby, A., Hall, N., Radford, A., and Zuerner, R. 2015. Complete genome sequence of Leptospira interrogans serovar Bratislava, Strain PigK151. Genome Announcements.3(3). pii: e00678-15. doi: 10.1128/genomeA.00678-15.

Witchell, T.D., Eshghi, A., Nally, J.E., Hof, R., Boulanger, M.J., Wunder, E.A., Ko, A.I., Haake, D.A. and Cameron, C.E. 2014. Post-translational modification of LipL32 during Leptospira interrogans infection. PLoS Neglected Tropical Diseases. 8(10):e3280. doi: 10.1371/journal.pntd.0003280.

Houston, S., Taylor, J.S. and Cameron, C.E. 2014. Spirochaetes. Encyclopedia of Life Sciences. John Wiley & Sons, Inc. Chichester http://www.els.net/ [DOI: 10.1002/9780470015902.a0000466.pub3]

Houston, S., Russell, S., Hof, R., Roberts, A.K., Cullen, P., Irvine, K., Smith, D.S., Borchers, C.H., Tonkin, M.L., Boulanger, M.J., and Cameron, C.E. 2014. The multifunctional role of the pallilysin-associated Treponema pallidum protein, Tp0750, in promoting fibrinolysis and extracellular matrix component degradation. Molecular Microbiology. 91:618-634. PMC3954913.

Cameron, C.E. and S.A. Lukehart. 2014. Current status of syphilis vaccine development: need, challenges, prospects. Vaccine. 32:1602-1609. PMC3951677.

Smith, B.C., Y. Simpson, M.G. Morshed, L.L.E. Cowen, R. Hof, C. Wetherell, and C.E. Cameron. 2013. Syphilis diagnosis – new proteins for a new perspective. Journal of Clinical Microbiology. 51:105-111. PMC3536202.

Eshghi, A., K. Lourdault, G. Murray, T. Bartpho, R.W. Sermswan, M. Picardeau, B. Adler, B. Snarr, R. L. Zuerner, and C.E. Cameron. 2012. Leptospira interrogans catalase is required for resistance to H2O2 and for virulence.  Infection and Immunity. 80:3892-3899. PMC3486042.